Microbiomes new research frontier – Audio

Friday, March 4th, 2016

Microbiomes new research frontier

Garret Suen, Assistant Professor
Department of Bacteriology
UW-Madison College of Agricultural and Life Sciences
gsuen@wisc.edu
(608) 890-3971

3:03 – Total Time
0:14 – What is a microbiome
0:30 – Microbiomes large and small
0:41 – Life driven by microbiomes
1:10 – Cow rumen a microbiome
1:50 – Powerful new technology
2:29 – Will touch medicine and agriculture
2:55 – Lead out

TRANSCRIPT

 Sevie Kenyon: The new frontier of microbiomes. We are visiting today with Garret Suen, department of Bacteriology, University of Wisconsin-Madison in the College of Agricultural and Life Sciences and I’m Sevie Kenyon. Garret, start out by defining for us, what is a microbiome?

Garret Suen: A microbiome is the collection of all microbes that lives within a given environment. So what we are talking about, are all the bacteria, all the archaea, all the fungi, and all of the viruses that live within any type of community. Continue reading

Tim Donohue, the power of microbes and the pull of Rockaway Beach

Monday, February 1st, 2016
Tim-Donohue-Lab_0_1

Tim Donohue, director of the Great Lakes Bioenergy Research Center (GLBRC) and UW-Madison professor of bacteriology, says microbiology is enjoying a renaissance period: “Innovation in biology and microbiology can help provide food, health, and energy for a growing population while also ensuring that future generations have access to resources they need to thrive on the planet. That prospect really excites me.”

Long before Tim Donohue became a bacteriology professor and the director of the Great Lakes Bioenergy Research Center (GLBRC), he was a teenage beach cleaner and would-be biologist growing up on the boardwalk of New York City’s Rockaway Beach.

“I was fascinated by the change in the seasons, the tides, the weather, the wildlife,” Donohue says of those early years. “Exposure to the ocean really led me to biology.”

Rockaway, the largest urban beach in the U.S., fed Donohue’s interest in science but it also gave him the cash he needed for college. As a young man, Donohue held two summer jobs, performing routine vehicle maintenance for the National Park Service during the day and emptying Rockaway’s trashcans as the sun set every night.

“I was the first child in our family to go to college,” Donohue says. “My mother had a sixth grade education, my father had an eighth grade education. I think there was probably an implicit expectation that I would go to college, but the idea of me becoming a scientist, getting a Ph.D., that was not really on the table.”

As a college student at the Polytechnic Institute of Brooklyn in the early 1970s, Donohue  met Professor Ron Melnick, who introduced him to the world of microbes. The most ancient form of life on earth, microbes are microscopic, single-cell organisms such as bacteria, fungi, and viruses. Donohue’s love of all things biology had found a tiny new focus.

“I was just fascinated by the power of microbes,” Donohue says, “and by their global impact on our everyday lives. They shaped this planet’s history, they’re central to many of the foods we eat, and they have a huge impact – sometimes positive, sometimes negative – on our bodies and agriculture.”

Melnick also encouraged Donohue to begin working in his lab or, as Donohue puts it, “to drive the car instead of just reading the driver’s manual.” Donohue definitely drove that car, heading to the Pennsylvania State University to pursue a doctorate in microbiology and then on to the University of Illinois at Urbana-Champaign for a post-doctoral research fellowship.

Now a professor of bacteriology at the University of Wisconsin–Madison, Donohue likes to describe his research as “unlocking the secrets” of microbes.

“Microbes have been doing interesting chemistry on this planet for billions of years,” Donohue says. “We can learn a lot from studying how they do what they do.”

Individual bacteria use different strategies to obtain the energy and nutrients they need to live. Some microbes harvest sun light, others have a sweet tooth and prefer to eat sugars. Some digest aromatics, while still others grow by using energy from splitting hydrogen.

“We knew about many of these different processes when I was a student”, Donohue says, “but now, with genomics tools such as DNA sequencing, we can see the actual blueprints of these processes.”

Possessing these exact blueprints gives scientists the information they need to design new pathways that coax bacteria to perform new and desirable tasks.

“In our GLBRC projects, we’re trying to re-task native pathways and engineer next-generation microbial factories that can manufacture valuable fuels and chemicals from renewable wastes.”

While biofuel production is one area of research that will continue to gain from advances in microbiology, the field of microbiology is exceptionally wide-ranging, and enjoying what Donohue calls a “renaissance period.”

Donohue was recently among a group of leading scientists who published a call for a new, government-led “Unified Microbiome Initiative” in the scientific journals Science andNature. A more coordinated research effort, the authors argue, would go a long way toward harnessing the power of microbes to benefit agriculture and energy production and help address issues such as climate change and disease.

“We’re really at an inflection point,” Donohue says. “Innovation in biology and microbiology can help provide food, health, and energy for a growing population while also ensuring that future generations have access to resources they need to thrive on the planet. That prospect really excites me.”

Donohue, who has published in collaboration with other researchers for much of his career, is a firm believer in coordinated, cross-disciplinary research. As director of the GLBRC, he oversees a team representing a wide array of disciplines and specialties collaborating to overcome a major energy challenge: developing a robust and environmentally sustainable pipeline for biofuels.

“It’s been eye-opening for me to see how GLBRC’s team approach has allowed us to make advances much faster than I ever imagined,” Donohue says. “I never thought we would’ve accumulated the body of knowledge, produced the number of papers, and generated the amount of intellectual property that we have.”

In early 2015, GLBRC reported the filing of its 100th patent application. And to date, the Center has published approximately 850 papers, many of which represent collaborations with researchers from over 32 U.S. states and 24 countries.

Tim Donohue, son of New York City’s so-called Irish Riviera, now occupies an office with a view of the west end of UW–Madison’s campus and is candid about drawing inspiration from the Wisconsin Idea, or the notion that the university should improve people’s lives well beyond the classroom.

“GLBRC really is a proud contributor to the Wisconsin Idea,” Donohue says. “We are doing relevant research that will benefit the state, the region, and the country. It’s been an honor to be a part of this work.”

The GLBRC is one of three Department of Energy Bioenergy Research Centers created to make transformational breakthroughs and build the foundation of new cellulosic biofuels technology. For more information on the GLBRC, visit www.glbrc.org or visit us on twitter @glbioenergy.

This story was originally published on the Great Lakes Bioenergy Research Center news page.

Researchers collaborate to break down lignin and advance biofuels

Thursday, January 14th, 2016

To tackle what many consider the next frontier in biofuels research, the Great Lakes Bioenergy Research Center (GLBRC) recently joined forces with the Joint BioEnergy Institute (JBEI) in Emeryville, California. The focus of their collaboration? Lignin, a glue-like compound in the cell wall of most living plants that gives them their sturdiness.

While lignin accounts for up to one third of plant carbon, it’s also the most difficult part to break down and remains a formidable obstacle to accessing the valuable sugars contained within biomass. As a result, the biofuels and paper industries mostly treat it as a waste product, isolating it to be burned or discarded.

GLBRC lignin Kate Helmich

Kate Helmich analyzes bacterial enzymes called LigF and LigE that break particular chemical bonds within larger lignin molecules.

But GLBRC and JBEI researchers hope to change all that by bringing their collective expertise to the challenge of unraveling lignin’s strong and unique molecular bonds. With two new studies already complete, the payoff for their effort could be significant.

“If we can convert lignin from an undesirable byproduct into a starting material for advanced biofuels and other lucrative chemicals,” says Tim Donohue, GLBRC director and UW–Madison professor of bacteriology, “we would dramatically change the economics of tomorrow’s biorefineries.”

The researchers began by studying bacterial enzymes that cleave specific chemical bonds inside larger lignin molecules with the idea of creating a single new enzyme to break down lignin. That turned out to be a difficult task, however, because lignin molecules are similar to snowflakes: they have a multitude of spatial configurations, even within a single plant, and each of them requires a different approach to deconstruction.

“Making a single enzyme would be like trying to make a glove that’s designed for your left hand fit on your right hand,” explains Kate Helmich, co-first author of one of the studies and a recent PhD graduate of UW–Madison’s biochemistry department. “Our two hands are different configurations of the same fingers, and lignin is like a chain of many different hands. Degrading that entire chain would require an enzyme, or glove, that can attach to both the left and the right hands within it.”

Nature has instead evolved multiple, highly specialized bacterial enzymes that work in concert to break down lignin, each of them cleaving different sets of chemical bonds in the complex molecule.

Though a single lignin-cracking “master hybrid enzyme” remains elusive, the study informs future enzyme engineering efforts and sets the stage for more GLBRC and JBEI collaborations to convert lignin and other parts of plant biomass into biofuels and valuable chemicals.

GLBRC’s Helmich and Daniel Gall share first authorship, ​with JBEI’s Jose Henrique Pereira, on a paper recently published in the Journal of Biological Chemistry; and former GLBRC researcher and Rice University professor George Phillips, Jr. is senior author. In a sister study led by JBEI (currently slated for publication), the team reports new insights into bacterial enzymes that could someday help produce aromatic compounds of great interest to the chemical industry from lignin.

“It is exciting to see that our collaboration has resulted in the simultaneous publication of these two important papers,” Donohue says. “Collaboration is at the center of everything we do at GLBRC. We look forward to doing more of this mutually beneficial work with JBEI and other academic and industrial partners to advance the growing biofuels industry.”

GLBRC is one of three Department of Energy-funded Bioenergy Research Centers created to make transformational breakthroughs that will form the foundation of new cellulosic biofuels technology. For more information on the GLBRC, visit www.glbrc.org.

This story was originally published on the Great Lakes Bioenergy Research Center website.

Scientists: Harnessing microbes could help solve hunger, health, chemical and energy problems

Thursday, October 29th, 2015

While scientists learn more with each passing study about the way the invisible lives of fungi, bacteria, viruses and other microscopic organisms intersect with much larger plants and animals as well as the planet, Tim Donohue and a group of prominent scientists want to make sure researchers don’t miss the giant forest for the tiny trees.

Donohue, a UW–Madison bacteriology professor and director of the Great Lakes Bioenergy Research Center, joined 17 other scientists from around the world and representing a wide range of disciplines on Oct. 28 to lay out a case for an organized approach to harnessing the power of microbes to tackle many of the world’s most pressing problems.

Tim Donohue, professor of bacteriology

Tim Donohue

Led by Jeff F. Miller, a microbiology professor at the University of California, Los Angeles, in the journal Science, and microbiologist Nicole Dubilier of Germany’s Max Planck Institute for Marine Microbiology, in Nature, the authors proposed a Unified Microbiome Initiative to supply key knowledge and techniques to address sustainable agriculture, chemical and energy production, climate change, disease and more.

Discoveries ancient and modern illustrate the importance of microbes.

The geological record provides evidence of how ancestors of today’s microbes helped shape our planet. Microbes provide the oxygen we breathe, break down contaminants in water, help us digest and absorb nutrients in our food, and pass nitrogen in soil to hungry plants.

Yeast leavens bread and ferments beer, but also has a hand in the production of insulin, vaccines and industrial chemicals. Viruses may help guide normal development in animals, are a source of gene exchange in the oceans, and have stepped up as powerful tools for the study of genetics and delivery of gene therapies.

But much of what researchers have learned about the specific workings of the ubiquitous little “bugs” remains walled up within each microbe or group of microbes’ home range — or the particular branch of science practiced by the experts, according to Donohue.

“A variety of people in the academic community, the private sector and the federal government really feel it’s time to take the analysis of microbial communities to the next level,” he says. “That means moving beyond using genome sequences to obtain a census of which microbes are where, and tackling the next big challenge: understanding what communities of microbes are doing in different environments.”

A Unified Microbiome Initiative could help collect and process enormous amounts of information about dozens or hundreds or thousands of types of microbes that are born, eat, excrete, fight, die and evolve together — all the while making a fundamental difference in the environment they inhabit.

“What we need is an influx of people from other fields to work with the biochemists and microbiologists and engineers who have typically studied microbes in isolation,” Donohue says.

If scientists could accurately model communities of microbes, and anticipate how changes at the microscopic level make for changes visible on the human scale, they can anticipate problems and use microbes to create next-generationsolutions to grand societal problems.

“That has enormous potential for the health of the planet and the health of people. It could make personalized medicine work. It could create new energy sources and be the catalyst for next-generation bio-based manufacturing. It could grow food and provide clean water,” Donohue says. “Twenty years from now we may look back at this as a watershed time where we began to take information on microbes and use them as predictors of human health and influencers of planetary activities on a new scale.”

That would require organization and support for research that develops tools for exploring microbial communities and put those tools in the hands of multidisciplinary teams of scientists and engineers, according to the researchers writing in Nature and Science.

Donohue sees enthusiasm from U.S. governmental agencies and major private research philanthropic organizations for a collective push like the BRAIN Initiative, launched in 2013 by the White House’s Office of Science and Technology Policy (OSTP) to advance neuroscience. The initiative incorporates hundreds of millions of dollars in research supported by federal agencies, the pharmaceutical and medical imaging industries, and nonprofits like the Kavli Foundation.

OSTP and the Kavli Foundation have separately organized recent meetings where scientists fleshed out a vision of a Unified Microbiome Initiative.

“It’s important that this be an international effort,” Donohue says. “This is a problem the United States has the brain power and the resources to be a leader in. But to do it right, it is critical that we take advantage of the expertise that exists around the globe. Because these are problems — medicine, energy, food — we face collectively.”

UW–Madison — where researchers are investigating the roles microbes play in lifelong health, plant productivity, wastewater treatment, manufacturing and more — is uniquely positioned to play a role in a concerted effort to broaden the way science studies and makes use of microbes.

“We have expertise in every arena that needs to be pulled in to contribute, beginning with a world-class cadre of microbiologists and a spirit of collaboration,” Donohue says. “Our medical school, veterinary school, strong engineering, agricultural experts, leaders in oceanography — if we can find a way here to connect teams of these people with researchers in analytics and computation, we can be a model for the country and the world.”

This story was originally published on the UW News site.

Mycologist says our close relatives break the bounds of biology

Monday, October 26th, 2015

The mushroom nicknamed “death cap” made headlines this summer when it poisoned Syrian refugees fleeing through Eastern Europe.

But it was cooperation, not toxicity, that attracted Anne Pringle to Amanita phalloides. The fungus consumes carbon compounds released by tree roots, says the UW-Madison associate professor of botany and bacteriology, and in return helps the roots absorb soil nutrients. “I was interested in the evolution of cooperation,” she says, “and fungi and plants are models for understanding how symbiotic species interact — how the relationship is policed and maintained.”

Amanita_phalloides_1

The European Amanita phalloides (“death cap”) mushroom. Photo: Archenzo/Creative Commons. Banner photo: The hallucinogenic toadstool Amanita muscaria is also invading new terrain. Photo courtesy of Rytas Vilgalys.

Long before the Syrian refugees were poisoned, Pringle says, immigrants in California were dying as the death cap expanded its range along the West Coast. “A. phalloides poisoning is a really unpleasant way to go,” she says. “There’s intestinal distress, diarrhea. Then you feel fine during a ‘honeymoon’ that lasts several hours or more. Death can come through liver and kidney failure.”

In large swaths of California, she says, “the mushrooms are so abundant, it’s hard to believe they’re simply a neutral addition to the landscape.”

Fungi are essential recyclers of material and members of ecosystems, but they are “a cryptic part of biodiversity, largely hidden in the soil,” Pringle says. “We don’t have a fungicide that is species specific, and if you drenched its habitat with fungicide, would that be effective and safe for the environment?”

Fungi as a group are poorly known, says Pringle, who was an associate professor of organismic and evolutionary biology at Harvard University before coming to Wisconsin. “The fungi are basically a jungle of species. There are an estimated one to 10 million species, and we have names for 100,000, which suggests how little we know. You can go outside and pick up some soil, put it in a gene sequencer, and you will see a heck of a lot of species that do not match anything seen before.”

Pringle’s studies of spore dispersal show that fungi actually have some mobility. “Typically, people think fungi just release spores passively to the wind or water,” she says, “but it seems that they have evolved a mechanism to make sure the spores are released when they are most likely to spread.”

Pringle, along with Damon Smith and Mehdi Kabbage, two UW-Madison assistant professors of plant pathology, is studying the spring-like mechanism that parasitic soybean fungi use to catapult their spores into the wind. Such a mechanism, she says, “challenges the idea of fungi as passive entities.”

Anne_Pringle

Anne Pringle

Pringle says fungi are puzzling. “If there is a rule in biology, I can think about how it does not apply to fungi. They challenge our preconceptions of how biology works.”

The overall oddness of fungi appears in the genes. In almost all organisms, every cell contains identical genes — it is a difference in gene activation that distinguishes a blood cell from a nerve cell. “But in fungi, one part looks very different genetically from another,” Pringle says, “so the entity you call an individual from a physical perspective encompasses many different genetic individuals. What is going on?”

Cooperation, not competition, is the archetypal relationship between fungi and many of their hosts, especially plants, Pringle says. “How you think about biology is shaped by the organisms you work with. If you think about fungi, you start with symbiosis.”

The goal of her ecological studies, she says, “is to slowly chip away at this overwhelming amount of not-knowledge. How does the pattern of fungal biodiversity vary across regions, and across the planet? How are species being moved? What does extinction look like in the fungal kingdom?”

Many people are surprised to find that the genomes of fungi and people are so closely related, Pringle observes. “If biology is to be true, we have to build rules that work for the whole of life. Maybe there are no general rules, and if that’s true, that’s also interesting. Understanding these issues is a critical part of our job, and it gets me up every day. If we are going to search for life on other planets, we need to think about how the entire spectrum of life works.”

This story was originally published on the UW-Madison News site.

Ancestors of land plants were wired to make the leap to shore

Tuesday, October 6th, 2015
liverworts, moss, fern

Liverwort plants, pictured here with moss and a fern, are an ancient lineage of land plant. Fossils suggest they may have been some of the first plants to colonize land 450 million years ago. Photo: Jean-Michel Ane lab, UW-Madison.

When the algal ancestor of modern land plants made the transition from aquatic environments to an inhospitable shore 450 million years ago, it changed the world by dramatically altering climate and setting the stage for the vast array of terrestrial life.

The genetic and developmental innovations plants used to make the leap to land have been enduring secrets of nature. Now, an international team of researchers, writing in the Proceedings of the National Academy of Sciences (PNAS), reveals that the aquatic algae from which terrestrial plant life first arose were genetically pre-adapted to form the symbiotic relationships with microorganisms that most land plants need to acquire nutrients from the soil.

The finding is important because it begins to flesh out the story of how the first land plants evolved from freshwater algae, formed critical symbiotic partnerships with microorganisms like fungi and bacteria, and made the world’s land masses habitable. What’s more, it could help with the development of biofuels. Understanding the genetic pathways involved could allow agronomists to unlock similar genes that are likely conserved in plants such as cereals and green algae, which are promising biofuel stock but require substantial amounts of chemical fertilizer.

“We were expecting that these mechanisms arose with land plants,” explains Jean-Michel Ane, a University of Wisconsin-Madison professor of bacteriology and agronomy and the senior author of the PNAS report. “The surprise was finding in algae the mechanisms we know allow plants to interact with symbiotic fungi.”

The discovery shows that the algae knew how to interact with beneficial microbes while it was still in the water, observes Pierre-Marc Delaux, who conducted the research as a postdoctoral fellow at UW-Madison and is now at the John Innes Centre in the U.K. “Without the development of this pre-adapted capability in algae, the Earth would be a very different place today,” says Delaux.

Jean-Michel Ane

Jean-Michel Ane

Many plant species depend on symbiotic relationships with microorganisms to thrive. The most famous are legumes and their beneficial association with nitrogen-fixing bacteria. Other plant species depend on relationships with fungi to chemically convert minerals in soil to forms that benefit the plant, notes Ane.

The efficient acquisition of mineral nutrients, says Ane, was likely one of the primary challenges for the earliest land plants.

“The association between plants, algae and fungi probably played a really important role in the ability of plants to colonize land,” he says. “In fact, many of us think early plants were able to colonize lands because they evolved the ability to associate with beneficial fungi.”

The genes required to encourage symbiosis between plants and microbes likely arose in a common ancestor of green algae and land plants, says Ane.

Prior to the new study, little was know about the associations between algae and fungi. The genetic pathways plants use to form a symbiosis with fungi were known in land plants called liverworts and hornworts, ancient lineages sister to all other land plant lineages. Liverworts thrive in damp environments worldwide and the oldest known liverwort fossils provide the earliest evidence of plants colonizing land.

“We had found these mechanisms in liverworts, but not algae previously,” explains Ane.

And while microorganisms had been found before in association with algae, they were believed to be pathogens, not symbionts. “Nobody had studied associations in these freshwater algae. We think some of these associations may be beneficial.”

Genetic features in plants, animals and microbes tend to be preserved and repurposed through evolutionary history. Discovering these pathways allowing associations with beneficial microbes in green algae and in cereals, which now require significant amounts of chemical fertilizer, could enable the engineering in plants of more efficient nutrient acquisition — significantly reducing the need for chemical fertilizers for food and bioenergy production.

The study was supported by grants from the National Science Foundation, UW-Madison and the Bill & Melinda Gates Foundation.

This story was originally published on the UW-Madison News site.

“Happy Days Study” meets the microbiome

Thursday, August 6th, 2015
Members of the Wisconsin Longitudinal Study (WLS) class of 1957

Members of the Wisconsin Longitudinal Study class of 1957 during a 50th reunion held in 2007. The WLS has evolved to become one of the longest-running social science studies ever undertaken and now provides valuable information about the group’s ongoing education, employment, health, family life and aging status. Photo: Jeff Miller

For almost 60 years, the Wisconsin Longitudinal Study (WLS) has closely followed the life course of roughly a third of Wisconsin high school graduates from the class of 1957.

Subjects of the project known as the “Happy Days Study” — one of the most consistent, comprehensive and expansive studies of aging and health in America — have contributed their time for repeated, highly detailed surveys of health, family life and employment. They have given access to medical and life histories, including diseases, health-related behaviors, cognitive status, psychological and physical well-being, and detailed geographical data showing where subjects have lived over the course of their lives. As new molecular assays have been developed, the WLS cohort has also contributed biological samples such as saliva, which can be genotyped.

Now, with the advent of new high-throughput genetic sequencing technologies, a new frontier beckons: the microbiome.

In our gut, each of us has a unique ecosystem composed of hundreds of species of microorganisms, acquired since birth from the environment, our food and the people closest to us. Together with their genes, this collection of microorganisms is known as the microbiome. Humans and other animals are utterly dependent on these microbial hitchhikers to do things like digest food, process nutrients, modulate the immune system and outcompete the pathogenic microbes that sometimes infect us.

Pamela Herd

Pamela Herd

“We know relatively little about the gut microbiome,” explains Pamela Herd, a professor in the University of Wisconsin-Madison’s Robert M. La Follette School of Public Affairs and the principal investigator of the WLS. “But one of the things that is so interesting about it is its plasticity. The broader environment seems to influence its composition.”

To date, studies of human gut microbiota have been limited. The largest study, conducted in 2012 and supported by the National Institutes of Health, sampled “healthy” human microbiomes from 256 people selected non-randomly from St. Louis and Houston. Researchers are also hamstrung by limited environmental information from their subjects. Things like diet, social interaction and where people live are known to influence the composition of the gut’s resident colony of microbes. There is also little known about the microbial communities that colonize the elderly. It is known that gut microbiota in the elderly are more varied from person to person, and that those differences can be associated with health, including frailty, inflammation and obesity.

Federico Rey

Federico Rey

To begin to address some of these limitations, Herd and her WLS colleagues have embarked on a novel collaboration with the lab of UW-Madison bacteriology Professor Federico Rey. With the help of the University of Wisconsin Survey Center, the WLS researchers have collected fecal samples from more than 400 participants in the WLS to begin to map out the health implications of the microbes that live in our gut as we grow old.

“This is not easy data to collect,” notes Rey, who participated in a landmark study while at Washington University showing that the composition of the microbes in the gut can significantly influence metabolism and obesity.

In that study, human microbiota samples were transplanted into germ-free mice to see, among other things, if the mouse recipients would mirror the metabolism or obesity of the human donor, which they in fact did.

“People who are obese have a different microbiome,” says Rey, “and we can colonize mice with human fecal samples to reflect aspects of that phenotype.”

The new effort by WLS and the collaboration with Rey is a rare marriage of biology and social science. The fact that the subjects of the WLS have been intensively tracked for almost 60 years, means the information found in their microbiomes can be correlated with where they lived, who they lived with, their health and employment histories, and even their psychological well-being. Such things as where someone has lived, for example, may be reflected in the gut microbiome because the germs we accumulate in our gut can come from things like soil.

germ-free mice

Nacho Vivas, lab manager at the Rey Lab in the Bacteriology Department at the University of Wisconsin-Madison, tends to the individual enclosures of a group of germ-free mice in their sterile environment and provides them with fresh food. Photo: Bryce Richter

Observations drawn from WLS data can be tested in the context of the microbiome. For example, WLS data suggest that growing up poor can have a “sustained influence on health and mortality across the life course.” In another context, being raised on a farm — as 20 percent of the WLS sample were — seems to have a significant positive influence on health and longevity.

“We have decades of information on social relationships,” says Herd, “and we’re wondering about things like how social relationships affect the microbiome. Every time we shake hands or kiss, we exchange microbes. Some studies have shown that people who are isolated are likely to die younger, but why?”

Exploring the microbiome in the context of the WLS data may help provide some answers because environment and social interaction seem to play such a large role in the composition and changes to the microbiome.

And like genetic information, it may be possible in the future to predict health or prescribe medical interventions based on what your microbiome says about you, says Rey.

“Environment matters,” he argues, “and the things we are going to be looking at promise to take our understanding of that to an entirely new level.”

The new work is being supported in part by a $90,000 interdisciplinary research award from the UW-Madison Office of the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation.

This story was originally published on the UW-Madison News site.

Bugs to biofuels – Audio

Friday, June 26th, 2015

Bugs to biofuels

Gina Lewin, Research Assistant, Currie Lab
Department of Bacteriology
UW-Madison College of Agricultural and Life Sciences
glewin@wisc.edu
Phone (608) 262-7538

3:05 – Total Time
0:17 – Challenge to break down biomass
0:49 – The leaf cutter ant
1:22 – Answers in ant trash
1:53 – Microbial communities
2:15 – Why this is different
2:47 – Ants with a Twitter account
2:58 – Lead out

TRANSCRIPT

Sevie Kenyon: The path to biofuels led by bugs, we’re visiting today with Gina Lewin, Department of Bacteriology University of Wisconsin-Madison in the College of Agricultural and Life Sciences, and I’m Sevie Kenyon. Gina, tell us what you’re doing with insects related to biofuels.
Gina Lewin: I’m interested in how we can breakdown plant biomass for making biofuels, so breaking down plant biomass is really important if we want to make biofuels from the non food parts of plants like the stalks of the corn, or from poplar trees or different prairie grasses. What I’m doing is looking at insect systems that have evolved to be really good at breaking down plant biomass into simple sugars. Continue reading

Drugs from bugs – Audio

Friday, June 12th, 2015
Ant worker covered in white bacterium. The bacterium produces antibiotics that protect the colony from pathogens. Photo by Don Parson

Ant worker covered in white bacterium. The bacterium produces antibiotics that protect the colony from pathogens. Photo by Don Parson

Heidi Horn, Research Assistant
Department of Bacteriology
UW-Madison College of Agricultural and Life Sciences
hahorn8@gmail.com
Phone (608) 890-0237

Drugs from bugs
3:03 – Total Time
0:15 – Connecting insects to medicine
0:46 – Antibiotics found in ant colonies
1:05 – Long time from the ant to the market
1:25 – About the ants
1:42 – Searching for ants
2:21 – Keeping Panama ants alive in Wisconsin
2:41 – For more information
2:55 – Lead out

TRANSCRIPT

Sevie Kenyon: Bugs and drugs, we are visiting today with Heidi Horn Department of Bacteriology University of Wisconsin-Madison in the College of Agricultural and Life Sciences, and I’m Sevie Kenyon.

Heidi, how do we connect bugs with medicine?

Heidi Horn: I know it seems like a strange, strange connection, but our lab is actually doing that every day. We actually study a tropical ant called leaf cutter ants, and they are very cool in many ways. They actually grow a fungus for their food so they are farmers, but it gets even cooler than that. They have an association with a bacterium that makes an antibiotic that protects them so we use antibiotics when we go to the doctor and so almost in the same sense the ants are using antibiotics. Continue reading