Probing the mysteries of RNA
For people who know about RNA mostly from its place in the central dogma of biology — DNA ➙ RNA ➙ Protein — this story may hold a number of surprises.
That handy equation, taught in Biology 101 courses around the globe, sums up the flow of genetic information in living organisms: how our DNA gets copied into RNA, which then gets converted into proteins, the building blocks of our cells, our bodies.Originally, the RNA referred to in this equation—messenger RNA, or mRNA, the type that codes for proteins—was the only kind known to science. However, over the years, it has become clear that there are many, many other kinds.
“The world of RNA has proven to be a big and fascinating place,” says Marv Wickens, a CALS professor of biochemistry and leading pioneer in RNA research. “I’ve come to think of it as a Fellini movie, full of strange and unexpected characters.”
These Felliniesque characters are all the non-coding RNAs that exist in nature—the kinds that don’t code for proteins. They go by names like small interfering RNA, piwi-interacting RNA, microRNA, long ...
Wednesday, September 3rd, 2014